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NESS 2006 Annual Meeting
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Gastric Electrical Stimulation As A Treatment For Gastroparesis
Stacie E Perlman, Randolph B Reinhold, Steven Yood
Hospital of Saint Raphael, New Haven, CT

Objective: The purpose of this study is to investigate the effect of gastric electrical stimulation (GES) on solid phase gastric emptying, total symptom score (TSS), health-related quality of life (HRQOL), and patient satisfaction in patients with drug-refractory idiopathic or diabetic gastroparesis
Design: Prospective, non-randomized, single-center case-series
Setting: Community urban hospital
Patients: Consecutive patients presenting between 2002 and 2005 with refractory gastroparesis
Interventions: Gastric electrical stimulator placement (Enterra Therapy, Medtronic, Minneapolis, MN)
Main Outcome Measures: Gastric emptying, total symptom scores, health-related quality of life (SF-36).
Results: Twelve patients received GES. One patient was lost to follow-up; one patient died of unrelated illness. The average percentage of gastric retention preoperatively was 86.4% at 2 hours. Postoperatively, this value dropped to 40.7%. After 6 months, all patients' gastric retention decreased by an average of 45% (p<0.05). The average TSS preoperatively was 44 (range 25-56) compared to 29.5 (range 4-42) postoperatively. Overall, 86% of patients had improved TSS scores, with an average of 17 points improvement. HRQOL scores were broken into physical and mental components. The average preoperative physical HRQOL component score was 30.1, with a postoperative score of 36.0. The preoperative mental component HRQOL score of 35.3 improved to 45.9 postoperatively. The average improvement in physical score was 5.9 (p<0.05) while the average improvement in mental score was 10.6 (p>0.05). 100% of patients stated that they would undergo the procedure again.
Conclusions: Gastric electrical stimulation improved solid phase gastric emptying, symptom scores, and health-related quality of life in patients with drug refractory gastroparesis.


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