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Clinical Outcomes in Patients With Severe Diabetic Foot Ulcers
Treated With and Without Hyperbaric Oxygen
George A Perdrizet¹, Patrick Worth², Justin Moher², Brian Solomon², Caesar Anderson², Christine Shapter^2
1University of Connecticut/Hartford Hospital, Hartofrd, CT;²University of Connecticut/Hartford Hospital, Hartford, CT

Objective: Efficacy of Hyperbaric Oxygen Therapy (HBO₂T) for treatment of diabetic foot ulcers (DFU, Wagner Class 3 & 4) has been established. We wish to present our experience in 25 diabetic patients who received HBO₂T in accordance with UHMS Guidelines and compare to 25 diabetic patients that did not receive HBO₂T.
Design/Setting/Patients: Observational study, sequential series of 25 patients with a DFU (Wagner Class 3 or 4) that received = 30 HBO₂T treatments over a 6-week period, and for whom there was 10 week follow-up. Demographics, wound parameters and vascular assessments were obtained from the patients’ clinical records. A comparison of data sets was performed using the Fisher Exact test for diachotomous data and Student’s t test for continuous data. Statistical significance was reached if p = 0.05. IRB approval was obtained prior to data extraction.
Main Outcome Measures: include percentage healed/not healed and percentage of amputations (minor and major) at 10 weeks after completion of HBO₂T.
Results: A total of 50 patients met inclusion criteria as having a Wagner Class 3 or 4 DFU, 25 of whom received = 30 HBO₂T..

	DFU- with HBO2T	DFU-without HBO2T
Number of Patients	25	25
Mean age (yrs)	64±14	75±12
Mean wound size (cm2)/range	20±22 (0.2-84)	15.4±15(0.5-46)
Mean initial tissue oxygen tension (mmHg)	31±18	42 ±22
% healed (No. healed/not healed)	56 (14/11)	32 (8/17)
% amputation (No. amp/ not amp)	16 (4/21)	32 (8/17)

Conclusion: Diabetic patients treated with HBO₂T for Wagner’s Class 3 or 4 foot ulcers had 56% chance of healing and 15% chance of amputation. Diabetic patients not receiving HBO₂T had a 30% chance of healing and a 30% chance of amputation.

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