New England Surgical Society (NESS)
Search NESS
  Home
  Annual Meeting
  Annual Resident and Fellow Research Day
  Members
      Member Directory
      Members Only
  Scholars Foundation
  Job Board
  Awards
  Journal of the American College of Surgeons
  Newsletters
  Committees
  Contact NESS

2010 Annual Meeting Abstracts

Back to Program


Elastic Scattering Spectroscopy (ESS) for Discrimination of Benign from Malignant Disease in Thyroid Nodules
Hyunsuk Suh, *Samuel Kim, *Susannah Orzell, *Ousama A'amar, *Eladio Rodriguez, *Stephanie Lee, *Irving Bigio, Jennifer E Rosen
Boston University, Boston, MA

Objective
• Elastic Scattering System (ESS) is an optical-biopsy technique mediated by fiber-optic probes and spectrometer that are sensitive to cellular and subcellular morphological features. We assessed the diagnostic potential of ESS to differentiate benign from malignant thyroid nodules.

Design
• Conduct an IRB approved study of ESS data from thyroid nodules from patients undergoing thyroidectomy.
• Co-register the ESS reading sites with a blinded independent histopathology review.

Setting
• Study conducted at an academic institution.
Patients
• Patients undergoing total or near total thyroidectomy with thyroid nodules.
Interventions
• None
Main Outcome Measures:
• 36 patients (21 benign, 15 malignant) or 900 spectra (500 benign, 400 malignant) were analyzed. Averaged Spectra data were analyzed using principal component analysis then linear discriminant analysis.
• Using the “Leave-one-out” method, sensitivity and specificity were obtained.
• Subclass analyses were performed on patients with an indeterminate FNA on cytology (N=17; 10 benign, 7 malignant).
Results
• The sensitivity and the specificity of ESS were 75% and 95%, respectively. The positive predictive value (PPV) and negative predictive value (NPV) were 0.92 & 0.83.
• The indeterminate FNA subclass analysis revealed sensitivity and specificity of 0.86 & 1.00, while PPV and NPV were 1.00 and 0.91

Conclusions
• ESS can differentiate benign from malignant thyroid nodules with high PPV and NPV using ex vivo specimens.
• Compared to FNA, ESS has much higher PPV.
• In indeterminate FNA specimens, this high PPV could potentially prevent a significant number of unnecessary surgeries.
• ESS could potentially provide minimally invasive, operator-independent real time assessment of thyroid nodules.


Back to Program

 

Copyright © 2018 New England Surgical Society. All Rights Reserved.
Read Privacy Policy.